Carol A. Bagnell

Carol A. Bagnell.

Professor
Foran Hall 126
Phone: 848-932-6334
Email: carol.bagnell@rutgers.edu




Curriculum Vitae


Research

Studies in my laboratory focus on improving our understanding of (1) maternal programming of development by testing the lactocrine hypothesis and (2) the role of the hormone relaxin in reproduction. 

Maternal contributions to offspring development begin at conception, continue during gestation, but do not end at birth. The role of nursing as a means of extending communication between mother and offspring into the postnatal period is of interest in our laboratory. Our group defined the term ‘lactocrine’ as a means of maternal delivery of milk-borne bioactive factors into the circulation of offspring as a consequence of nursing. Porcine milk contains relaxin that is transmitted into the peripheral circulation of neonates only if they are allowed to nurse. These studies indicate that a window of opportunity for transmission of milk-borne bioactive factors, including relaxin, from mother to neonate is open during the first few days of life. Data from our porcine model provide compelling evidence that maternal programming of neonatal female reproductive tract development requires lactocrine signaling from birth.

Current studies center on the short-term effects of milk-borne factors on neonatal development as well as the long-term consequences of lactocrine signaling on reproductive health and fertility in adulthood. Studies focus on transcriptomic and proteomic changes in neonatal and adult reproductive tissues as a function of nursing. Since all mammals evolved to nurse, this research has broad implications for understanding maternal contributions to postnatal reproductive tract programming in both humans and domestic animals.

Experience

Title Location Year
Director Graduate Program in Endocrinology and Animal Biosciences
Rutgers University
2014 - present
Chair Dept. of Animal Sciences, Rutgers University 2008 - 2014
Professor Dept. of Animal Sciences, Rutgers University 2002
Visiting Scientist Merck & Co., Inc.
Dept. of Atherosclerosis & Endocrinology
2001 - 2002
Associate Professor Dept. of Animal Sciences, Rutgers University 1994
Associate Chair Dept. of Animal Sciences, Rutgers University 1995
Assistant Professor Dept. of Animal Sciences, Rutgers University 1988
Associate Researcher Pacific Biomedical Research Center (PBRC)
Dept of Anatomy and Reproductive Biology
University of Hawaii
1987
Assistant Researcher Pacific Biomedical Research Center (PBRC)
Dept of Anatomy and Reproductive Biology
University of Hawaii
1985

Education

Degree Location Year
Postdoc University of Hawaii 1984
Ph.D. Medical College of Georgia 1983
M.S. West Virginia University 1976
B.S. Glassboro State College, NJ 1974

Current Research Associates and Graduate Students

Ashley George Ph.D. student Maternal Programming of the Neonatal Uterus
Teh-Yuan Ho Research Associate

Publications