Noradrenergic control of food intake. Overeating episodes are sometimes accompanied by a feeling of a loss of control over what or how much is being consumed. A loss of control is a core subjective component of binge eating in humans with a clinically diagnosed eating disorder or other eating pathologies. Our laboratory uses rodent models to determine the dietary consequences of aberrant eating behaviors on the neural controls of feeding. In particular, it has been demonstrated that brain norepinephrine (NE) is involved in responding to stressors and maintaining attentional focus. Based on what is known about the anatomy, physiology, and function of the dorsal noradrenergic pathway, we hypothesize that dysregulation of brain NE neurons is involved in dietary induced overeating. This noradrenergic dysregulation is likely to be involved in the subjective feeling of a loss of control involved in binge eating. We will test our hypothesis by using behavioral, immunohistochemical, and electrophysiological techniques in rats and mice.
Raspberry ketone and dietary supplements effects on the feeding and the metabolic outcomes of obesity. There has been a dramatic rise in the consumer use of dietary supplements for weight management. Raspberry ketone [4-(p-hydroxyphenyl)-2-butanone] is derived from the fruit of the red raspberry (Rubus idaeus) and has purported antiobesity properties. Despite the supplement's consumer popularity, raspberry ketone has not been systematically tested to determine effectiveness for weight loss. The overall objective of our research is to determine the mechanisms by which raspberry ketone decreases feeding and prevents the metabolic consequences of diet-induced obesity. This project will use diet-induced obese (DIO) mice to investigate the acute and long-term effects of raspberry ketone on body weight homeostasis and metabolic signatures. We will test our hypothesis by using a combination of in vivo and in vitro experiments and also examine the potential for supplement-induced hepatic and intestinal pathologies.
|Postdoc||Johns Hopkins University School of Medicine||2010|
Penn State University College of Medicine
|M.S.||Laboratory Animal Sciences
Drexel University College of Medicine
Penn State University