![[Dept. of Animal Sciences]](../../images/animalsciences.gif "[Dept. of Animal Sciences]"){kind=small}
| Associate Professor Department of Physiology and Biophysics UMDNJ-Robert Wood Johnson Medical School 683 Hoes Lane Kessler S219E Piscataway, NJ 08854 Tel: 732-235-5658 zachowrj@umdnj.edu |
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Research
During each wave of ovarian follicular maturation, granulosa cells (GC) and theca cells within the growing cohort of ovarian follicles differentiate into estradiol-17ß (E 2 )- and androgen-producing cells, respectively. This dynamic process is regulated by the pituitary gonadotropins (FSH and LH) as well as a host of growth factors and cytokines. Ovarian steroidogenesis is critical for maintaining female fertility; thus, any factors which affect steroidogenesis can impact reproductive viability. The main emphasis of our research program is to better understand the effect of select cytokines and growth factors on ovarian steroidogenesis.
Experience
Title |
Location |
Year |
| Associate Professor and Medical Physiology Course Director | Robert Wood Johnson Medical School |
2004 |
| Assistant Professor | Southern Illinois University | 1998 |
Education
Degree |
Location |
Year |
Post doc |
Reproductive Medicine, UC San Diego | 1997-1998 |
Post doc |
Obstetrics and Gynecology, Cedars-Sinai Medical Center/UCLA | 1993-1997 |
Ph.D. |
Physiology, University of KS Medical Center | 1993 |
B.S. |
Biologic Sciences, University of WI-Milwaukee | 1990 |
Professional Societies
Society for the Study of Reproduction
International Association of Medical Science Educators
American Physiological Society
Editorial Board
Journal of Endocrinology
Courses
Course Director: Medical Physiology (PHYS 6000)
http://www.umdnj.edu/webctweb
Co-course Director: M1 Integrated Cases (MDC 6004)
http://www.umdnj.edu/webctweb/
Representative Publications
Kabis S, Schneider S, Das KM, Zehring W, Zachow R. Cases for Medical Physiology Small Group Discussions. MedEdPORTAL, 2007. Available from http://www.aamc.org/mededportal, ID = 530.
Uzumcu M, Zachow, RJ. Environmental endocrine disruptors: consequences on the ovary and female reproductive function in mammals. In press, Reproductive Toxicology, Special Edition: The Fetal Basis of Adult Disease, 2007.
Uzumcu M, Pan Z, Chu Y, Kuhn PE, Zachow RJ. Immunolocalization of the hepatocyte growth factor (HGF) system in the rat ovary and the anti-apoptotic effect of HGF in rat ovarian granulosa cells in vitro. Reproduction, 132: 291-299, 2006.
Zachow RJ, Uzumcu M. The methoxychlor metabolite, 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane, inhibits steroidogenesis in rat ovarian granulosa cells in vitro. In press, Reproductive Toxicology, 2006.
Zachow RJ, Woolery JK. The effects of hepatocyte growth factor on cyclic nucleotide-dependent signaling and steroidogenesis in rat ovarian granulosa cells in vitro. Biology of Reproduction, 67: 454-459, 2002.