![[Dept. of Animal Sciences]](../../images/animalsciences.gif "[Dept. of Animal Sciences]"){kind=small}
| Professor Rutgers, The State University of New Jersey Department of Nutritional Sciences Thompson Hall, Room 130 Tel: 732-932-7418 Fax: 732-932-6837 watford@aesop.rutgers.edu http://nutrition.rutgers.edu/faculty/watford.htm |
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Research
Glutamine plays major roles in the inter-organ transport of nitrogen, carbon, and energy within the body and is becoming a significant nutrient added to both enteral and parenteral formulae. The research emphasis of this laboratory is the role and regulation of glutamine metabolism as it relates to gluconeogenesis and nitrogen excretion.
Experience
Title |
Location |
Year |
| Professor | Nutritional Sciences, Rutgers, The State University of New Jersey |
2007-present |
| Visiting Scientist | Centro de Biotechnologia Animal y Terapia Genica (CBATEG), Universitat Autonoma de Barcelona, Spain |
2006 (sabbatical leave) |
| Adjunct Member | Centro de Biotechnologia Animal y Terapia Genica (CBATEG), Universitat Autonoma de Barcelona, Spain |
2004-present |
Director |
Graduate Program in Nutrition Rutgers, The State University of NJ |
July 1991-July 1996;July 2002-June 2005 |
Visiting Scientist |
Biochemistry and Molecular Biology Faculty of Veterinary Medicine Universidad Autonoma de Barcelona |
2001 |
Associate Professor |
Nutritional Sciences |
1990-2007 |
Visiting Scientist |
Laboratoire de Nutrition et Securite Alimentaire, Institut Nationale de la Recherche AgronomiqueJouy-en-Josas, France |
1997 (Sabbatical leave) |
Assistant Professor |
Nutrition and Biochemistry |
1982-1989 |
Instructor |
Biochemistry |
1980-1982 |
Visiting Instructor |
BiochemistryLoma Linda University School of Medicine |
1982 |
Education
Degree |
Location |
Year |
Postdoctoral training |
Case Western Reserve University School of Medicine, Dept. of Biochemistry |
1979-1980 |
Postdoctoral training |
Universite de MontrealLaboratoire de NephrologieHotel Dieu Hopital |
1977-1979 |
D.Phil. |
Oxford University |
1977 |
B.Sc. |
Trent Polytechnic Nottingham (UK) |
1974 |
National Committees
American Society for Nutrition
Graduate Education Committee (1990-94, Chair 1993/94, 1996-1999, Chair 1999/99)
Macronutrient Research Interest Group,Steering Committee Member 1999-2002, 2005-2007,
Program Representative 2002/03,
Chair-elect 2007/08
Seimens Westinghouse High School Science and Technology Competition,
Judge (stages I-V, semifinalist and finalist selection) 2001-present
New Jersey Diabetes Council, Member 2005-present
Judge (Stages I-V, Semifinalist and Finalist Selection), Siemens Westinghouse High School Science & Technology Competition, 2001, 2002
American Society for Nutritional Sciences (American Institute of Nutrition), Graduate Nutrition Education Committee (1990-94, Chair 1993-94, 1996-99, Chair 1998-99)
Professional Societies
American Diabetes AssociationAmerican Physiological Society
American Society for Biochemistry and Molecular Biology
American Society for Nutritional Sciences
Biochemical Society, U.K.
Editorial Positions
Member, Editorial Committee, Annual Review of Nutrition, 2007-present
Guest Member, Editorial Planning Committee (2006), Annual Review of Nutrition, vol 28 Associate Editor, Journal of Nutrition (2003-present)
Contributing Editor, Nutrition Reviews (2000-present)
Editorial Board, Journal of Nutrition (1999-present)
Reviews Editor, Biochemical Journal (1997-1999)
Editorial Board, Biochemical Journal (1991-1999)
Journal Club Correspondent in Metabolic Regulation, Trends in Biochemical Sciences (1988-1991)
Current Grad Students
Courses Taught
Undergraduate Courses
| Course | Course Title |
| 709:400 | Advanced Nutrition I |
| 709:481 | Seminar in Nutrition (Metabolic Regulation: a problem based approach) |
Graduate Courses
| Course | Course Title |
| 709:515 | Introduction to Nutrition Research Methods |
| 709:553 | Nutrition: A Biochemical & Physiological Basis |
Representative Publications
Huang, Y.F., Wang, Y. and Watford, M. (2007) Glutamine directly down-regulates the level of glutamine synthetase protein in C2C12 skeletal muscle cells. J. Nutr. in press
Manso-Filho, HC., Watford, M. and McKeever, K.H. (2007) Novel findings regarding Glut-4 expression in adipose tissue and muscle in horses. The Veterinary Journal in press
Wang, Y. and Watford, M. (2007) Glutamine, insulin and glucocorticoids regulate glutamine synthetase expression in C2C12 myotubes, HepG2 hepatoma cells and 3T3 L1 adipocytes. Biochim. Biophys. Acta 1770: 594-600
Watford, M. (2007) Lowered concentrations of branched chain amino acids lead to impaired growth and neurological problems: insights from a branched chain -keto acid dehydrogenase complex kinase-deficient mouse model. Nutr. Rev. 65, 167-172
Stipanuk, M.H. and Watford, M. (2006) Amino Acid Metabolism, in Biochemical, Physiological & Molecular Aspects of Human Nutrition (Stipanuk, M.H. ed 2nd edition) Saunders, Chapter 14, pp 360-418
Watford, M. (2006) Regulation of Fuel Utilization in Response to Food intake, in Biochemical, Physiological & Molecular Aspects of Human Nutrition (Stipanuk, M.H.ed, 2nd Edition) Saunders, Chapter 16, pp 541-565
Ribnicky, D.M, Poulev, A, Watford, M, Cefalu, W.T. and Raskin, I. (2006) The effect of Tarralin, an extract of Artemisia dracunculus L., on blood glucose parameters in diabetic animal models. Phytomedicine 13, 550-557
Watford, M. (2005) Is the small intestine a gluconeogenic organ? Nutrition Reviews 63: 356-360
Watford, M. and Wu, G. (2005) Glutamine metabolism in uricotelic species: variation in skeletal muscle glutamine synthetase, glutaminase, glutamine content and rates of protein synthesis. Comp. Biochem. Physiol. 140B, 607-614
Watford, M. (2004) The Ornithine Cycle, Encyclopedia of Biological Chemistry, Elsevier Science 172-177
Brosnan, J.T. and Watford, M. (2004) Starvation: metabolic changes, Encyclopedia of Life Science (www.ELS.net), Nature Publishing Group
Watford, M. (2003) The Urea Cycle: Teaching intermediary metabolism in a physiological setting. Biochem. Mole. Biol. Ed.31, 289-297
Patterson, B.W., Horowitz, J.F., Wu, G., Watford, M., Coppack, S.W. and Klein, S. (2002) Regional Muscle and Adipose Tissue Amino Acid Metabolism in Lean and Obese Humans. Am. J. Physiol. Endocrinol. Metab. 282: E931-E936
Watford, M. (2002) Net Inter-Organ Transport of L-Glutamate in the Rat Occurs Via the Plasma not Via Erythrocytes. J. Nutr. 132: 952-956
Wu, G., Meininger, C.J., Kelly, K., Watford, M. and Morris, S.M. Jr. (2000) A Cortisol Surge Mediates the Enhanced Expression of Pig Intestinal Pyrroline 5-Carboxylate Synthase During Weaning. J. Nutr. 130: 1914-1919
Watford, M., Darcy-Vrillon, B. and Duee, P.-H. (2000) Dietary Glutamine Suppresses the Appearance of Endogenous Glutamine in the Rat. Metabolism, 49: 141-145
Watford, M. (2000) Glutamine and Glutamate Metabolism Across the Liver Sinusoid. J. Nutr. 130: 983S-985S
Wu, G., Chung-Bok, M.-I., Vincent, N., Kowalski, T.J., Choi, Y-H. and Watford, M. (1998) Distribution of Phosphate Activated Glutaminase Isozymes in the Chicken: Absence from Liver but Presence of High Activity in Pectoralis Muscle. Comp. Biochem. Physiol. 120B, 285-290
Kowalski, T.J., Wu, G. and Watford, M. (1997) Rat Adipose Tissue Amino Acid Metabolism In Vivo as Assessed by Microdialysis and Arterio-Venous Techniques. Am. J. Physiol. 273: E613-E622
Chung-Bok, M.I., Vincent, N., Jhala, U. and Watford, M. (1997) Rat Liver Glutaminase: Identification of the Full-Length Coding Sequence and Characterization of a Functional Promoter. Biochem. J. 324: 193-200
Curthoys, N.P. and Watford, M. (1995) Regulation of Glutaminase Expression and Glutamine Metabolism. Ann. Rev. Nutr. 15: 133-159