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Research
My long-term research plan is to understand how alcohol, natural estrogens, and environmental estrogens alter neuroendocrine, reproductive, and immune functions to increase the risk of the development of tumors, including prolactinomas and mammary tumors. I am also studying the feasibility of gene therapy and tissue-targeted transgenic procedures to understand and prevent these tumors.More information
Experience
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Title
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Location
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Year
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| Distinguished Professor | Endocrine Program, Center for Alcohol Studies, Department of Animal Sciences; Rutgers, The State University of New Jersey |
2001
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| Chair and Professor | Department of Animal Sciences; Rutgers, The State University of New Jersey |
1999
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| Director | Alcohol and Drug Abuse Program, Washington State University |
1998
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| Adjunct Professor | Department of Genetics and Cell Biology, Washington State University |
1989
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| Adjunct Professor | Program of Pharmacology and Toxicology, Washington State University |
1989
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| Professor | Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology; Washington State University |
1996
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| Associate Professor (Tenured) | Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology; Washington State University |
1988
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| Assistant Professor | University of California, San Diego, Department of Reproductive Medicine |
1983
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| Research Associate | Michigan State University, Department of Physiology |
1980
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| Visiting Postdoctoral Fellow | Yale University School of Medicine, Section of Neurological Surgery |
1979
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| Postdoctoral Research Assistant | University of Oxford, Department of Anatomy |
1979
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Education
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Degree
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Location
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Year
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| D. Phil. | Oxford University, UK |
1979
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| Ph.D. | Calcutta University, India |
1975
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| M.S. | Calcutta University, India |
1972
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| B.S. | Calcutta University, India |
1970
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National Committees
Federal Advisory Board, Member of NIH Study Section (Neurotox 4)
Charter Member, American Neuroendocrine Society, 1997-present
Public Communication Committee, Research Society on Alcoholism, 1999-2001
Editorial Positions
Editorial Board member: Neuroendocrinology, 1987-1990; Endocrinology,
1989-1992
Current Research faculty, Postdocs, and Graduate Students
Dr. Lindsey Grandison, Associate Professor, UMDNJ, Microarray analysis of genes of prolactinomas and fetal alcohol
Dr. Nadka Boyadjieva, Research Assistant Professor, Brain control of immune function
Dr. Kirti Chaturvedi, Research Assistant Professor, TGF-ß structure-function relationship
Dr. Peter Kuhn, Postdoc, Effect of fetal alcohol on programmed cell death in ß-endorphin neurons
Dr. Hemanta Koley, Postdoc, Effect of fetal alcohol on reproductive function
Dr. Soichi Omizu, Postdoc, Role of cell-cell communications in estrogen-induced pituatary tumors
Dr. Cuiping Chen, Postdoc, Molecular mechanisms of ethanol-induced ß-endorphin neurons death
Madhavi Dokur, Ph.D. student, Role of central ß-endorphin neurons in regulation of spleenic natural killer cell cytolytic activity and how alcohol consumption alters the function of ß-endorphin-regulated NK cell function
Sonia Cohen, Ph.D. student, Mechanisms of alcohol and estrogen actions on lactotropic cell proliferation
Kristina Willoeghby, George H. Cook, Alkaline phenols effect on sexual brain differentiation
Courses
| 16:067:510 | Neuroendocrinology |
Representative Publications
De A., Boyadjieva, N., Pastorcic M., Reddy, B.V. and Sarkar, D.K.
1994. cAMP and ethanol interaction in regulating programmed death and
diferentiation of hypothalamic ß-endophinergic neurons. J. Biol. Chem.
269:26697-26705.
Pastorcic, M., De A., Boyadjieva, N., Vale, W. and Sarkar, D.K.
1995. Reduced transforming growth factor ß1 expression and function in
the lactotropes during estrogen induced tumorigenesis. Cancer Research.
55:4892-4898.
Sarkar DK, Rivier C, Weinberg J and Redei E 1996 Neuroendocrine-immune
axis of alcoholics. Alcoholism: Clinical and Experimental Research. 20:256A-259A
Boyadjieva N., B. Reddy and D.K. Sarkar. 1997 Forskolin delays
the ethanol-induced desensitization of hypothalamic ß-endorphin neurons
in primary cultures. Alcoholism: Clinical and Experimental Research. 21:477-482
Sarkar DK, Pastorcic M, De A, Engel M, Moses H and Ghasemzadeh
MB 1998 Role of TGF-ß type I and TGF-ß type II receptors in the TGF-ß1-regulated
gene expression in pituitary prolactin-secreting lactotropes. Endocrinology
138:3620-3628.
Chun T-Y, Gregg D, Sarkar DK and Gorski J. 1998 Differential regulation
by estrogens of growth and prolactin synthesis in pituitary cells suggests
only a small pool of estrogen receptors is required for growth. Proceeding
National Academic of Science USA 95:2325-2330.
Simasko SM, Boyadjieva N, De A, Sarkar DK 1999 Effect of ethanol
on calcium regulation in rat fetal hypothalamic cells in culture. Brain
Research 824:89-96.
Hentges S, Pastorcic M, De A, Boyadjieva N, Sarkar D.K. 2000 Opposing
actions of two TGF-ß isoforms on pituitary lactotropic cell proliferation.
Endocrinology 141:1528-1535.
Hentges S, Sarkar D.K. 2000 TGF-ß3 stimulates lactotropic cell
growth by increasing b-FGF from folliculo-stellate cells. Endocrinology
141:859-867.
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