![[Dept. of Animal Sciences]](../../images/animalsciences.gif "[Dept. of Animal Sciences]"){kind=small}
Assistant Professor |
 |
Research
My research interests concentrate on understanding molecular mechanisms of bioadaptation. Currently, we investigate contribution of microRNA to remodeling of gene expression by alcohol and to the development of tolerance. We are pursuing these questions using human samples, animal models and cell cultures, as well as a variety of cellular and molecular techniques, including nucleic acid and protein isolation and electrophoresis, classical and real-time PCR, microarrays, SNPs analysis, mammalian cell culture, Northern and Western analysis, immunofluorescence, transient transfections, immunoprecipitation, and ChIP.
Experience
Title |
Location |
Year |
| Assistant Professor | Department of Animal Sciences Rutgers University, New Brunswick, NJ |
2009 |
| Research Assistant Professor | Department of Psychiatry UMMS, Worcester, MA |
2007-2009 |
| Instructor in Psychiatry | Department of Psychiatry UMMS, Worcester, MA |
2005-2007 |
| Senior Postdoctoral Fellow | Department of Neurobiology UMMS, Worcester, MA |
2000-2005 |
| Postdoctoral Fellow | Molecular Endocrinology Laboratory UMMS, Worcester, MA |
1997-2000 |
| Instructor in Biochemistry | Molecular Endocrinology Laboratory MCPE, Warsaw, Poland |
1995-1997 |
| Technician | Molecular Endocrinology Laboratory MCPE, Warsaw, Poland |
1995 |
Education
Degree |
Location |
Year |
| Postdoc | University of Massachusetts Medical School | 1997 |
| Ph.D. | MCPE Warsaw, Poland | 1995 |
| M.D. | Warsaw Medical School Warsaw, Poland |
1987 |
| B.A. | Warsaw College Warsaw, Poland |
1983 |
Professional Societies
The International Behavioural and Neural Genetics Society (IBANGS)
American Association for the Advancement of Science (AAAS)
New England Society for Microscopy (NESM)
Research Society on Alcoholism (RSA)
Society for Neuroscience (SfN)
American Society of Human Genetics
Current Projects
miRNA genetics in alcoholism
miRNA regulation of gene expression in alcohol tolerance and withdrawal
Representative Publications
Pietrzykowski AZ. A molecular biologist considers the corollary of misbehaving ion channels. Nature. 2008, October 16, 7215. Not peer-reviewed.
Martin GE, Friesen RM, Penta KL, Hendrickson LM, Pietrzykowski AZ, Tapper AR, Treistman SN. Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol. Accepted to PNAS on September 12, 2008.
Pietrzykowski AZ, Friesen RM, Martin GE, Puig SI, Nowak C, Wynne PM, Siegelmann H, Treistman SN. Post-transcriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol. Neuron, 2008 July 31, 59:74-287.
Pietrzykowski AZ, Friesen RM, Nowak C, Martin GE, Puig SI, Wynne PM, Treistman SN. miRNA regulation of gene expression underlies tolerance to alcohol. Genes, Brain and Behavior, 2008. Meeting symposium summary. Not peer-reviewed.
Martin GE, O’Connell RJ, Pietrzykowski AZ, Treistman SN, Ethier MF, Madison JM. Interleukin (IL)-4 activates large-conductance, calcium-activated, potassium (BKCa) channels in human airway smooth muscle cells. Exp Physiol. Epub 2008 Apr 10; 2008 Jul, 93(7):908-18.
Yuan C, O’Connell RJ, Wilson A, Pietrzykowski AZ, Treistman SN. Acute alcohol tolerance is intrinsic to the BKCa protein, but is modulated by the lipid environment. J Biol Chem. Epub. 2007 Dec 15; 2008 Feb 22, 283(8):5090-8.
Farwell AP, Dubord-Tomasetti SA, Pietrzykowski AZ, Leonard JL. Dynamic nongenomic actions of thyroid hormone in the developing rat brain. Endocrinology. 2006 May, 147(5):2567-74.
Roberto M, Treistman SN, Pietrzykowski AZ, Weiner J, Galindo R, Mameli M, Valenzula F, Zhu PJ, Lovinger D, Zhang TA, Hendricson AH, Morrisett R, Siggins GR. Actions of acute and chronic ethanol on presynaptic terminals. Alcohol Clin Exp Res. 2006 Feb, 30(2):222-32. Meeting symposium summary. Not peer-reviewed.
Pietrzykowski AZ, Nowak C, Treistman ST. Temporal regulation of BK channel splice variants by ethanol. Alcohol Clin Exp Res. 29 (5): 51A-51A Suppl. S MAY 2005. RSA Meeting abstract. Not peer-reviewed.
Farwell AP, Dubord-Tomasetti SA, Pietrzykowski AZ, Stachelek SJ, Leonard JL. Regulation of cerebellar neuronal migration and neurite outgrowth by thyroxine and 3,3',5'-triiodothyronine. Brain Res Dev Brain Res. 2005 Jan 1, 154(1):121-35.
Pietrzykowski AZ, Martin GE, Puig SI, Knott TK, Lemos JR, Treistman SN. Alcohol tolerance in large-conductance, calcium-activated potassium channels of CNS terminals is intrinsic and includes two components: decreased ethanol potentiation and decreased channel density. J Neurosci. 2004 Sep 22, 24(38):8322-32.
Martin G, Puig S, Pietrzykowski AZ, Zadek P, Emery P, Treistman S. Somatic localization of a specific large-conductance calcium-activated potassium channel subtype controls compartmentalized ethanol sensitivity in the nucleus accumbens. J Neurosci. 2004 Jul 21, 24(29):6563-72.
Nauman A, Puzianowska-Kuznicka M, Pietrzykowski AZ, Grzesiuk W, Luczak J Nauman J. Iodothyronine-5’-deiodinase in the atrium and ventricle of the rat heart. Polish J. Endocrinology, 1998, 49:261-270.
Pietrzykowski AZ, Nauman A. Nuclear receptors for vitamin A derivatives. Polish J. Endocrinology, 1996, 3:293-312. A review.
Nauman A, Nauman J, Pietrzykowski AZ, Lazecki D, Dutkiewicz S, Tanski Z, Witeska A, Kauczak M. The Low T3 Syndrome in patients with kidney cancer - effect of cancer differentiation. Polish J. Endocrinology, 1996, 47:143-149.
Bednarczuk T, Pietrzykowski AZ, Slon M, Nauman A. Effects of pharmacological doses of iodine on thyroxine-5'-deiodinase activity in rat thyroid. Polish J. Endocrinology, 1993, 44:405-412.