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Research
My primary research focus is on the enzymes that break down proteins (proteases) and compounds that inhibit specific proteases (protease inhibitors) and the mechanisms by which they regulate the many biological and pathological processes (blood clotting, digestion, growth, metabolism, tissue remodeling, infection, cancer). Interests include:
- The role of proteases and their inhibitors in health and disease and in the intracellular removal of normal and abnormal proteins in physiological and pathological states
- Effect of antioxidants, reactive oxygen species, and environmental factors in heart disease, cancer, infection, and other pathological conditions in animals and humans and on the survival of animal species
- Utilizing proteases and their inhibitors as targets for the development of new drug treatments
Experience
|
Title
|
Location
|
Year
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| Associate Professor | Dept.
of Animal Sciences, Rutgers University |
1990
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| Assistant Professor | Dept. of Animal Sciences, Rutgers University |
1986
|
| Postdoctoral Fellow | Physiology and Biophysics, Harvard Medical School |
1983
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| Research Assistant | Biochemistry, University of Arizona |
1981
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| Research Assistant | Nutrition and Food Science, University of Arizona |
1979
|
| Research Assistant | Clinic for Neuromuscular Disease, University of Arizona |
1977
|
| Teaching Assistant | Exercise Science, University of Massachusetts |
1975
|
Education
|
Degree
|
Location
|
Year
|
|
Postdoc
|
Harvard Medical School |
1986
|
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Ph.D.
|
University of Arizona |
1983
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M.S.
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University of Massachusetts |
1977
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B.A.
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Syracuse University |
1975
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A.A.
|
Colby Sawyer College |
1973
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Representative Publications
Fagan JM,
Rex SE, Hayes-Licitra SA, Waxman L. 1999
L-Arginine reduces right heart hypertrophy in hypoxia-induced pulmonary
hypertension. Biochem.Biophys Res Commun 254:100-103.
Fagan JM,
Ganguly M, Stockman H, Ferland LH, Toner M. 1999
Postranslational modifications of cardiac and skeletal muscle proteins
by reactive oxygen species after burn injury in the rat. Annals of Surgery
229:106-114.
Strack PR, Waxman
L, Fagan, JM. 1996
Activation of the multicatalytic endopeptidase by oxidants. Effects on
enzyme structure. Biochemistry 35(22):7142-7149.
Tiao G, Fagan
JM, Roegner V, Lieberman M, Wang J-J, Fischer JE, Hasselgren PO. 1996
Energy-ubiquitin-dependent proteolysis during sepsis is regulated by glucocorticoids.
J Clin Invest 97(2):339-348.
Fagan JM,
Waxman L. 1992
Characterization of the ATP-independent pathway in red blood cells that
degrades oxidant-damaged hemoglobin. J Biol Chem 267:23015-23022
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