![[Dept. of Animal Sciences]](../../images/animalsciences.gif "[Dept. of Animal Sciences]"){kind=small}
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Professor and Chair Rutgers, The State University of New Jersey School of Environmental and Biological Sciences Department of Animal Sciences Office 126 - Foran Hall Tel: 732-932-8165 x102 Fax: 732-932-6996 bagnell@aesop.rutgers.edu http://www.escrutgers.com/profiles/bagnell.htm |
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Research
Studies in my laboratory focus on the physiology of the hormone relaxin in the control of female reproductive tract development and remodeling. Relaxin, a member of the insulin-like family of hormones, has long been regarded as a hormone of pregnancy known for its trophic and connective tissue remodeling actions in the female reproductive tract that facilitate delivery at term and prepare the mammary gland for lactation. However, studies show that relaxin is not only a hormone of pregnancy but has multiple roles in non-pregnant animals and targets both reproductive and non-reproductive tissues. In fact, recent studies show that a developmentally-regulated, estrogen-sensitive relaxin receptor system is present in the porcine uterus and cervix from birth. In addition, porcine milk contains relaxin that is transmitted into the peripheral circulation of neonates only if they are allowed to nurse. These studies indicate that a window of opportunity for transmission of milk-borne relaxin from mother to neonate is open during the first few days of life. Thus, factors, such as relaxin, with the potential to control reproductive tract development during early postnatal life are communicated to the neonate in milk by way of a maternally driven ‘lactocrine’ mechanism. Currently, specific areas of research include:
- determining how milk-borne relaxin influences the developmental program and trajectory of uterine and cervical tissues.
- studying the interaction between relaxin and estrogen signaling pathways in regulating reproductive tissue growth.
- identifying molecular markers and mediators that control reproductive development (e.g. Hoxa, Wnt, estrogen and relaxin receptor family genes) and how they respond to hormonal and environmental perturbations.
- studying the effects of relaxin on non-reproductive targets including cardiac and immune systems.
Experience
Title |
Location |
Year |
| Chair | Dept. of Animal Sciences, Rutgers University | 2008 |
| Professor | Dept. of Animal Sciences, Rutgers University | 2002 |
| Visiting Scientist | Merck & Co., Inc. Dept. of Atherosclerosis & Endocrinology |
2001 2002 |
| Associate Professor | Dept. of Animal Sciences, Rutgers University |
1994 |
| Associate Chair | Dept. of Animal Sciences, Rutgers University | 1995 |
| Assistant Professor | Dept. of Animal Sciences, Rutgers University | 1988 |
| Associate Researcher | Pacific Biomedical Research Center (PBRC)/Dept of Anatomy and Reproductive Biology, University of Hawaii | 1987 |
| Assistant Researcher | PBRC/Department of Anatomy and Reproductive Biology, University of Hawaii | 1985 |
Education
Degree |
Location |
Year |
Postdoc |
University of Hawaii | 1984 |
| Ph.D. | Medical College of Georgia | 1983 |
| M.S. | West Virginia University | 1976 |
| B.S. | Glassboro State College, NJ | 1974 |
Professional Societies
American Association for the Advancement of Science
Endocrine Society
Sigma Xi
Society for the Study of Reproduction
Women in Endocrinology
Editorial Positions
Editorial Board, Reproductive Biology and Endocrinology, 2002 - present
Editorial Board, Domestic Animal Endocrinology, 2002 - 2005
Editorial Board, Biology of Reproduction, 1999 - 2004
Current Research Associates and Graduate Students
| Teh-Yuan Ho, Ph.D. | Research Associate | Molecular mechanisms of uterine development |
| Joseph Chen | Ph.D. student | Regulation of porcine uterine programming: Effects of neonatal estrogen and relaxin exposure |
| Amy Frankshun | Ph.D. student | The lactocrine role of relaxin in the developing female reproductive tract |
| Emily Lamprecht | Ph.D. student | Inflammatory responses of horses to intense exercise and effects of nutritional supplementation |
Former Research Associates and Graduate Students
| Students | Title | Location | |
| Wenbo Yan | Ph.D, 2005 | Post-doctoral Fellow | U of Michigan Ann Arbor, MI |
| Karen Santora | M.S., 2005 | Research Scientist | Merck and Co, Inc. Rahway, NJ |
| Jennifer Neumann | M.S., 2002 | Physician | Residency Charlotte, NC |
| Judy Lenhart | Ph.D., 1999 | Vice President Strategic & Scientific Services |
Medscape Woodbridge, NJ |
| Kathleen Ohleth | Ph.D.,1997 | Medical Writer | Precise Publications Bridgewater, NJ |
| Qi Zhang | Ph.D., 1994 | Pathologist | Columbia University New York, NY |
| Research Associates | |||
| Frank Petersen | Ph.D. | Research Scientist | NJ Dept of Agriculture Trenton, NJ |
| Peter Ryan | Ph.D. | Associate Professor | Animal Sciences Missisippi State U |
Courses
| 11:067:327 | Animal Reproduction |
| 11:067:430 | Animal Microtechniques and Tissue Culture |
| 16:067:502 | Physiology of Reproduction |
| 16:067:701 | Graduate Research in Animal Science |
Representative Publications
Bartol FF, Wiley AA, Bagnell CA. 2008. Epigenetic programming of porcine endometrial function and the lactocrine hypothesis. Reprod Dom Anim 43(2):281-287. PubMed
Yan W, Chen J, Wiley AA, Bartol FF, Bagnell CA. 2008. Relaxin and estrogen affect estrogen receptor , vascular endothelial growth factor and relaxin receptor expression in the neonatal porcine uterus and cervix. Reproduction 135:705-712. PubMed
Santora K, Rasa C, Visco D, Steinetz BG, Bagnell CA. 2007. Antiarthritic effects of relaxin, in combination with estrogen, in rat adjuvant-induced arthritis. J Pharmacol & Experimental Therapeutics Aug 322(2): 887-893. PubMed
Ho TY, Yan W, Bagnell CA. 2007. Relaxin-induced matrix metalloproteinase-9 expression is associated with the activation of the NF-kB pathway in human THP-1 cells. J Leukocyte Biology 81:1303-1310. PubMed
Masters RA, Crean BD, Yan W, Moss A, Ryan PL, Wiley AA, Bagnell CA, Bartol FF. 2007. Neonatal porcine endometrial development and epithelial proliferation affected by age and exposure to estrogen and relaxin. Domestic Anim Endocrinol 33: 335-346. PubMed
Lamprecht E D, Bagnell CA, Williams CA. 2007. Inflammatory responses to three
modes of intense exercise in Standardbred mares. Equine Sci. Soc. Proc. 20: 76-77.
Yan W, Wiley AA, Bathgate RAD, Frankshun AL, Lasano S, Crean BD, Steinetz BG, Bagnell CA, Bartol FF. 2006. Expression of LGR7 and LGR8 by neonatal porcine uterine tissues and transmission of milk-borne relaxin into the neonatal circulation by suckling. Endocrinology 147:4303-10. PubMed
Yan W, Ryan PL, Bartol FF, Bagnell CA. 2006. Uterotrophic effects of relaxin related to age and estrogen receptor activation in neonatal pigs. Reproduction 131:943-950. PubMed
Neumann J, Lazaris A, Huang YJ, Karatzas C, Ryan R, Bagnell CA. 2006. Production and characterization of recombinant equine prorelaxin. Domestic Anim Endocrinol 31:173-185. PubMed
Bartol FF, Wiley AA, Bagnell CA. 2006. Uterine development and endometrial programming. Reproduction Suppl 62:113-130. PubMed
Yan W, Wiley, AA, Bartol FF and Bagnell CA. 2005. Tissue-specific effects of relaxin on the reproductive tract of neonatal gilts. Ann N Y Acad Sci. 1041:132-5. PubMed
Bagnell CA, Yan W, Wiley AA, Bartol FF. 2005. Effects of relaxin on neonatal porcine uterine growth and development. Ann N Y Acad Sci. 1041:248-55. PubMed
Ho TY and Bagnell CA. 2005. Relaxin induces matrix metalloproteinase-9 through activation of nuclear factor kappa B in human THP-1 cells. Ann N Y Acad Sci. 1041:314-6. PubMed
Santora K, Rasa C, Ronan J, Visco D, Steinetz B, Bagnell CA. 2005. Effects of relaxin in a model of rat adjuvant-induced arthritis. Ann N Y Acad Sci. 1041:481-5. PubMed
Lenhart JA, Ryan PL, Ohleth KA, Palmer SS, Bagnell CA. 2002. Relaxin increases secretion of tissue inhibitor of matrix metalloproteinase-1 and -2 during uterine and cervical growth and remodeling in the pig. Endocrinology 143:91-98. PubMed
Ryan PL, Baum DL, Lenhart JA, Ohleth KM, Bagnell CA. 2001. Expression of uterine and cervical epithelial cadherin expression during relaxin-induced growth in pigs. Reproduction 122:929-937. PubMed
Lenhart JA, Ryan PL, Ohleth KM, Palmer SS, Bagnell CA. 2001. Relaxin increases secretion of matrix metalloproteinase-2 and -9 during uterine and cervical growth and remodeling in the pig. Endocrinology 142:3941-3949. PubMed
Ryan PL, Bennett-Wimbush K Vaala WE, Bagnell CA. 2001. Systemic relaxin in pregnant pony mares grazed on endophyte infected fescue: Effects of fluphenazine treatment. Theriogenology 56:471-483. PubMed
Kirkup K, Mallin A, Bagnell CA. 2000. Inhibition of pig granulosa cell adhesion and growth in vitro by immunoneutralization of epithelial cadherin. J Reprod & Fertility 120:275-281. PubMed
Ryan PL, Bennet-Wimbush K, Vaala W, Bagnell CA. 1999. Relaxin as a biochemical marker of placental insufficiency in the horse: a review. Pferdeheilkunde (Equine Health)15:622-626.
Lenhart JA, Ryan PL, Ohleth KM, Bagnell CA. 1999. Expression of connexin-26,-32 and -43 gap junction proteins in the porcine cervix and uterus during pregnancy and relaxin-induced growth. Biol Reprod 61:1452-1459. PubMed
Lenhart JA, Ohleth KM, Ryan PL, Palmer SS, Bagnell CA. 1999. Effect of relaxin on tissue inhibitor of metalloproteinase-1 and -2 in the porcine uterus and cervix. In: RA Greenwald, S Zuker, LM Golub (eds). Inhibition of Matrix Metalloproteinases: Therapeutic Applications, Annals of the NY Acad of Sciences Vol 878: 565-566. PubMed
Ohleth KM, Zhang Q, Lenhart JA, Ryan PL, Bagnell CA. 1999. Trophic effects of relaxin on reproductive tissue: Role of the IGF system. Steroids 64: 634-639. PubMed
Ohleth KM and Bagnell CA. 1999. Relaxin secretion and gene expression in porcine granulosa and theca cells are stimulated during in vitro luteinization. Biol Reprod 60: 499-507. PubMed
Lenhart JA, Downey BR, Bagnell CA. 1998. Connexin 43 gap junction protein expression during follicular development in the porcine ovary. Biol Reprod 58:583-590. PubMed
Wang-Lee JL, Lenhart JA, Ohleth KM, Ryan PL, Bagnell CA. 1998. Regulation of urokinase and tissue-type plasminogen activator by relaxin in the uterus and cervix of the prepubertal gilt. J Reprod Fertility 114: 119-125. PubMed
Ohleth KM, Zhang Q, Bagnell CA. 1998. Relaxin protein and gene expression in ovarian follicles of immature pigs. J Molecular Endocrinology 21:179-187. PubMed
Ryan P, Vaala W, Bagnell CA. 1998. Evidence the equine relaxin in a good indicator of placental insufficiency in the mare. Proceedings American Assoc Equine Practitioners 44: 62-63.
Ohleth KM, Lenhart JA, Ryan PL, Radecki SV, Bagnell CA. 1997. Relaxin increases insulin-like growth factors and IGF binding proteins of the pig uterus in vivo. Endocrinology 138:3652-3258. PubMed
Ryan PL, Valentine AF and Bagnell CA 1996. Expression of E-cadherin in the developing and adult pig ovary. Biol Reprod 55:1091-1097. PubMed