Associate Professor
Rutgers, The State University of New Jersey
Department of Animal Sciences

Office 102 - Bartlett Hall

Tel: 732-932-0535
Fax: 732-932-6996
bagnell@aesop.rutgers.edu

http://www.equinesciencecenterrutgers.com/profiles/bagnell.htm



Research

Studies in my laboratory focus on the control of reproductive tissue growth and remodeling and the role of cell-cell communication in this process. The production, biological action, and receptors for locally produced hormones, growth factors, and cell adhesion molecules are under investigation using biochemical, immunological, and molecular approaches. These studies include:

  • Mechanisms involved in relaxin-induced growth of pig reproductive tissue: Angiogenesis, connective tissue proteases, gap junctions, and the nature of the relaxin receptor.
  • Production of recombinant equine relaxin. A tool to predict at-risk pregnancies and complications at parturition.
  • Hormonal regulation of cell adhesion in normal and cancerous cells of the reproductive tract.

Experience

Title
Location
Year
Sabbatical Leave Merck & Co., Inc.
Dept. of Atherosclerosis & Endocrinology
2001
Associate Professor Dept. of Animal Sciences, Rutgers University
1994
Associate Chair Dept. of Animal Sciences, Rutgers University
1995
Assistant Professor Rutgers University
1988
Associate Researcher Pacific Biomedical Research Center (PBRC)/Dept of Anatomy and Reproductive Biology, University of Hawaii
1987
Assistant Researcher PBRC/Department of Anatomy and Reproductive Biology, University of Hawaii
1985


Education

Degree
Location
Year
Postdoc
University of Hawaii
1984
Ph.D. Medical College of Georgia
1983
M.S. West Virginia University
1976
B.S. Glassboro State College, NJ
1974


Professional Societies

American Association for the Advancement of Science
Endocrine Society
Sigma Xi
Society for the Study of Reproduction
Women in Endocrinology

Editorial Positions

Editorial Board, Biology of Reproduction. 1999-2004
Editorial Board, Biology of Reproduction, 1999-2004
Editorial Board, Domestic Animal Endocrinology, 2002 -2005


Current Graduate Students

Kimberly Kirkup, M.S. student, Role of E-cadherin during follicle development and differentiation

Shin-Wu Liu, Ph.D. student, To be determined

Jennifer Neumann, M.S. student, Production and characterization of recombinant equine relaxin

Wenbo Yan, Ph. D. student, Mechanism of relaxin action: Cross-talk with the estrogen receptor


Courses

11:067:327 Animal Reproduction
11:067:430 Animal Microtechniques
16:067:502 Physiology of Reproduction


Patent Filed

"Equine relaxin as a measure of treatment efficacy" by Peter Ryan and Carol Bagnell, filed with the US Patent and Trademark Office, Washington, D.C., February, 2002 Docket # 99-0099.

Representative Publications

Kirkup K, Mallin A, Bagnell CA. 2000. Inhibition of porcine granulosa cell adhesion and growth in vitro by immunoneutralization of epithelial cadherin. J Reprod & Fertility, in press.

Ryan PL, Bennet-Wimbush K, Vaala W, Bagnell CA. 1999. Relaxin as a biochemical marker of placental insufficiency in the horse: a review. Pferdeheilkunde (Equine Health)15:622-626.

Lenhart JA, Ryan PL, Ohleth KM, and Bagnell CA. 1999. Expression of connexin-26,-32 and -43 gap junction proteins in the porcine cervix and uterus during pregnancy and relaxin-induced growth. Biol Reprod 61:1452-1459.

Lenhart JA, Ohleth KM, Ryan PL, Palmer SS, Bagnell CA. 1999. Effect ofrelaxin on tissue inhibitor of metalloproteinase-1 and -2 in the porcine uterus and cervix. In: RA Greenwald, S Zuker, LM Golub (eds). Inhibition of Matrix Metalloproteinases: Therapeutic Applications, Annals of the NY Acad of Sciences Vol 878: 565-566.

Ohleth KM, Zhang Q, Lenhart JA, Ryan PL, Bagnell CA. 1999 Trophic effects of relaxin on reproductive tissue: Role of the IGF system. Steroids 64: 634-639.

Ohleth KM and Bagnell CA. 1999. Relaxin secretion and gene expression in porcine granulosa and theca cells are stimulated during in vitro luteinization. Biol Reprod 60: 499-507.

Lenhart JA, Downey BR and Bagnell CA. 1998. Connexin 43 gap junction protein expression during follicular development in the porcine ovary. Biol Reprod 58:583-590.

Wang-Lee JL, Lenhart JA, Ohleth KM, Ryan PL, Bagnell CA. 1998. Regulation of urokinase- and tissue-type plasminogen activator by relaxin in the uterus and cervix of the prepubertal gilt. J Reprod Fertility 114: 119-125.

Ohleth KM, Zhang Q, Bagnell CA. 1998. Relaxin protein and gene expression in ovarian follicles of immature pigs. J Molecular Endocrinology 21: 179-187.

Ryan P, Vaala W, Bagnell CA. 1998. Evidence the equine relaxin in a good indicator of placental insufficiency in the mare. Proceedings American Assoc Equine Practitioners 44: 62-63.

Ohleth KM, Lenhart JA, Ryan PL, Radecki SV, Bagnell CA. 1997. Relaxin increases insulin-like growth factors and IGF binding proteins of the pig uterus in vivo. Endocrinology 138:3652-3258.


Ryan PL, Valentine AF and Bagnell CA 1996. Expression of E-cadherin in the developing and adult pig ovary. Biol Reprod 55:1091-1097.

Lenhart JA, Ryan PL, Ohleth KA, Palmer SS, Bagnell CA. 2002. Relaxin increases secretion of tissue inhibitor of matrix metalloproteinase-1 and -2 during uterine and cervical growth and remodeling in the pig. Endocrinology 143:91-98.

Ryan PL, Baum DL, Lenhart JA, Ohleth KM, Bagnell CA. 2001. Uterine and cervical epithelial cadherin expression during relaxin-induced growth. Reproduction 122:929-937.

Lenhart JA, Ryan PL, Ohleth KM, Palmer SS, Bagnell CA. 2001. Relaxin increases secretion of matrix metalloproteinase-2 and -9 during uterine and cervical growth and remodeling in the pig. Endocrinology 142:3941-3949.

Ryan PL, Bennett-Wimbush K Vaala WE, Bagnell CA. 2001. Systemic relaxin in pregnant pony mares grazed on endophyte infected fescue: Effects of fluphenazine treatment. Theriogenology 56:471-483.

Kirkup K, Mallin A, Bagnell CA. 2000. Inhibition of pig granulosa cell adhesion and growth in vitro by immunoneutralization of epithelial cadherin. J Reprod & Fertility 120:275-281.

Ryan PL, Bennet-Wimbush K, Vaala W, Bagnell CA. 1999. Relaxin as a biochemical marker of placental insufficiency in the horse: a review. Pferdeheilkunde (Equine Health)15:622-626.

Lenhart JA, Ryan PL, Ohleth KM, Bagnell CA. 1999. Expression of connexin-26,-32 and -43 gap junction proteins in the porcine cervix and uterus during pregnancy and relaxin-induced growth. Biol Reprod 61:1452-1459.

Ohleth KM, Zhang Q, Lenhart JA, Ryan PL, Bagnell CA. 1999. Trophic effects of relaxin on reproductive tissue: Role of the IGF system. Steroids 64: 634-639.

Wang-Lee JL, Lenhart JA, Ohleth KM, Ryan PL, Bagnell CA. 1998. Regulation of urokinase and tissue-type plasminogen activator by relaxin in the uterus and cervix of the prepubertal gilt. J Reprod Fertility 114: 119-125.

Ohleth KM, Zhang Q, Bagnell CA. 1998. Relaxin protein and gene expression in ovarian follicles of immature pigs. J Molecular Endocrinology 21:179-187.

Lenhart JA, Downey BR, Bagnell CA. 1998. Connexin 43 gap junction protein expression during follicular development in the porcine ovary. Biol Reprod 58:583-590.

Ohleth KM, Lenhart JA, Ryan PL, Radecki SV, Bagnell CA. 1997. Relaxin increases insulin-like growth factors and IGF binding proteins of the pig uterus in vivo. Endocrinology 138:3652-3658.

Ryan PL, Valentine AF, Bagnell CA. 1996. Expression of E-cadherin in the developing and adult pig ovary. Biol Reprod 55:1091-1097.





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