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Research
Studies in my laboratory focus on the control of reproductive tissue growth and remodeling and the role of cell-cell communication in this process. The production, biological action, and receptors for locally produced hormones, growth factors, and cell adhesion molecules are under investigation using biochemical, immunological, and molecular approaches. These studies include:
- Mechanisms involved in relaxin-induced growth of pig reproductive tissue: Angiogenesis, connective tissue proteases, gap junctions, and the nature of the relaxin receptor.
- Production of recombinant equine relaxin. A tool to predict at-risk pregnancies and complications at parturition.
- Hormonal regulation of cell adhesion in normal and cancerous cells of the reproductive tract.
Experience
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Title
|
Location
|
Year
|
| Sabbatical Leave | Merck
& Co., Inc. Dept. of Atherosclerosis & Endocrinology |
2001
|
| Associate Professor | Dept.
of Animal Sciences, Rutgers University |
1994
|
| Associate Chair | Dept. of Animal Sciences, Rutgers University |
1995
|
| Assistant Professor | Rutgers University |
1988
|
| Associate Researcher | Pacific Biomedical Research Center (PBRC)/Dept of Anatomy and Reproductive Biology, University of Hawaii |
1987
|
| Assistant Researcher | PBRC/Department of Anatomy and Reproductive Biology, University of Hawaii |
1985
|
Education
|
Degree
|
Location
|
Year
|
|
Postdoc
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University of Hawaii |
1984
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| Ph.D. | Medical College of Georgia |
1983
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| M.S. | West Virginia University |
1976
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| B.S. | Glassboro State College, NJ |
1974
|
Professional Societies
American Association for the Advancement of Science
Endocrine Society
Sigma Xi
Society for the Study of Reproduction
Women in Endocrinology
Editorial Positions
Editorial Board, Biology of Reproduction. 1999-2004
Editorial Board, Biology of Reproduction, 1999-2004
Editorial Board, Domestic Animal Endocrinology, 2002 -2005
Current Graduate Students
Kimberly Kirkup, M.S. student, Role of E-cadherin during follicle development and differentiation
Shin-Wu Liu, Ph.D. student, To be determined
Jennifer Neumann, M.S. student, Production and characterization of recombinant equine relaxin
Wenbo Yan, Ph. D. student, Mechanism of relaxin action: Cross-talk with
the estrogen receptor
Courses
| 11:067:327 | Animal Reproduction |
| 11:067:430 | Animal Microtechniques |
| 16:067:502 | Physiology of Reproduction |
Patent Filed
"Equine relaxin as a measure of treatment efficacy" by Peter Ryan and Carol Bagnell, filed with the US Patent and Trademark Office, Washington, D.C., February, 2002 Docket # 99-0099.
Representative Publications
Kirkup K, Mallin A, Bagnell CA. 2000. Inhibition of porcine granulosa
cell adhesion and growth in vitro by immunoneutralization of epithelial
cadherin. J Reprod & Fertility, in press.
Ryan PL, Bennet-Wimbush K, Vaala W, Bagnell CA. 1999. Relaxin
as a biochemical marker of placental insufficiency in the horse: a review.
Pferdeheilkunde (Equine Health)15:622-626.
Lenhart JA, Ryan PL, Ohleth KM, and Bagnell CA. 1999. Expression
of connexin-26,-32 and -43 gap junction proteins in the porcine cervix
and uterus during pregnancy and relaxin-induced growth. Biol Reprod 61:1452-1459.
Lenhart JA, Ohleth KM, Ryan PL, Palmer SS, Bagnell CA. 1999. Effect
ofrelaxin on tissue inhibitor of metalloproteinase-1 and -2 in the porcine
uterus and cervix. In: RA Greenwald, S Zuker, LM Golub (eds). Inhibition
of Matrix Metalloproteinases: Therapeutic Applications, Annals of the
NY Acad of Sciences Vol 878: 565-566.
Ohleth KM, Zhang Q, Lenhart JA, Ryan PL, Bagnell CA. 1999 Trophic
effects of relaxin on reproductive tissue: Role of the IGF system. Steroids
64: 634-639.
Ohleth KM and Bagnell CA. 1999. Relaxin secretion and gene expression
in porcine granulosa and theca cells are stimulated during in vitro luteinization.
Biol Reprod 60: 499-507.
Lenhart JA, Downey BR and Bagnell CA. 1998. Connexin 43 gap junction
protein expression during follicular development in the porcine ovary.
Biol Reprod 58:583-590.
Wang-Lee JL, Lenhart JA, Ohleth KM, Ryan PL, Bagnell CA. 1998.
Regulation of urokinase- and tissue-type plasminogen activator by relaxin
in the uterus and cervix of the prepubertal gilt. J Reprod Fertility 114:
119-125.
Ohleth KM, Zhang Q, Bagnell CA. 1998. Relaxin protein and gene
expression in ovarian follicles of immature pigs. J Molecular Endocrinology
21: 179-187.
Ryan P, Vaala W, Bagnell CA. 1998. Evidence the equine relaxin
in a good indicator of placental insufficiency in the mare. Proceedings
American Assoc Equine Practitioners 44: 62-63.
Ohleth KM, Lenhart JA, Ryan PL, Radecki SV, Bagnell CA. 1997.
Relaxin increases insulin-like growth factors and IGF binding proteins
of the pig uterus in vivo. Endocrinology 138:3652-3258.
Ryan PL, Valentine AF and Bagnell CA 1996. Expression of E-cadherin
in the developing and adult pig ovary. Biol Reprod 55:1091-1097.
Lenhart JA, Ryan PL, Ohleth KA, Palmer SS, Bagnell CA. 2002. Relaxin
increases secretion of tissue inhibitor of matrix metalloproteinase-1
and -2 during uterine and cervical growth and remodeling in the pig. Endocrinology
143:91-98.
Ryan PL, Baum DL, Lenhart JA, Ohleth KM, Bagnell CA. 2001. Uterine
and cervical epithelial cadherin expression during relaxin-induced growth.
Reproduction 122:929-937.
Lenhart JA, Ryan PL, Ohleth KM, Palmer SS, Bagnell CA. 2001. Relaxin
increases secretion of matrix metalloproteinase-2 and -9 during uterine
and cervical growth and remodeling in the pig. Endocrinology 142:3941-3949.
Ryan PL, Bennett-Wimbush K Vaala WE, Bagnell CA. 2001. Systemic
relaxin in pregnant pony mares grazed on endophyte infected fescue: Effects
of fluphenazine treatment. Theriogenology 56:471-483.
Kirkup K, Mallin A, Bagnell CA. 2000. Inhibition of pig granulosa
cell adhesion and growth in vitro by immunoneutralization of epithelial
cadherin. J Reprod & Fertility 120:275-281.
Ryan PL, Bennet-Wimbush K, Vaala W, Bagnell CA. 1999. Relaxin as
a biochemical marker of placental insufficiency in the horse: a review.
Pferdeheilkunde (Equine Health)15:622-626.
Lenhart JA, Ryan PL, Ohleth KM, Bagnell CA. 1999. Expression of
connexin-26,-32 and -43 gap junction proteins in the porcine cervix and
uterus during pregnancy and relaxin-induced growth. Biol Reprod 61:1452-1459.
Ohleth KM, Zhang Q, Lenhart JA, Ryan PL, Bagnell CA. 1999. Trophic
effects of relaxin on reproductive tissue: Role of the IGF system. Steroids
64: 634-639.
Wang-Lee JL, Lenhart JA, Ohleth KM, Ryan PL, Bagnell CA. 1998.
Regulation of urokinase and tissue-type plasminogen activator by relaxin
in the uterus and cervix of the prepubertal gilt. J Reprod Fertility 114:
119-125.
Ohleth KM, Zhang Q, Bagnell CA. 1998. Relaxin protein and gene
expression in ovarian follicles of immature pigs. J Molecular Endocrinology
21:179-187.
Lenhart JA, Downey BR, Bagnell CA. 1998. Connexin 43 gap junction
protein expression during follicular development in the porcine ovary.
Biol Reprod 58:583-590.
Ohleth KM, Lenhart JA, Ryan PL, Radecki SV, Bagnell CA. 1997. Relaxin
increases insulin-like growth factors and IGF binding proteins of the
pig uterus in vivo. Endocrinology 138:3652-3658.
Ryan PL, Valentine AF, Bagnell CA. 1996. Expression of E-cadherin
in the developing and adult pig ovary. Biol Reprod 55:1091-1097.
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